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FLASH GENE
Symbol KCNJ15 contributors: mct/npt - updated : 10-09-2009
HGNC name potassium inwardly-rectifying channel, subfamily J, member 15
HGNC id 6261
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain    
Urinarykidneyrenal medulla  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • a C-terminal PDZ domain (Sindic 2009)
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • subfamily J
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having an extreme pH sensitivity which has implications for the role of this subunit as a homotetrameric channel (Pessia 2001)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts selectively with MPDZ to affect its cell surface expression (Sindic 2009)
  • interacts directly with KCNJ10 and CASR and can decrease their currents, which in turn could reduce recycling of K(+) for the basolateral Na(+)-K(+)-ATPase and thereby contribute to inhibition of Na(+) reabsorption (Huang 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes (T2DM)affecting lean individuals
    Variant & Polymorphism SNP SNP, rs3746876, in exon 4 (C566T), with T allele frequency among control subjects of 3.1p100, showed a significant association with T2DM affecting lean individuals (Okamoto 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS