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FLASH GENE
Symbol P2RX4 contributors: mct - updated : 11-02-2012
HGNC name purinergic receptor P2X, ligand-gated ion channel, 4
HGNC id 8535
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  highly
Nervousspinal cord    
Reproductivefemale systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion blood predominantly
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two short intracellular domains
  • two transmembrane spanning segments
  • a large extracellular loop
  • mono polymer homomer , heteromer , heptamer
    HOMOLOGY
    Homologene
    FAMILY P2X receptor family
    CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • purinoceptor, P2X4, ionotropic class, receptor for ATP acting as a ligand gated ion channel
  • P2RX4 as well as P2RY12 is involved in ATP-induced microglial chemotaxis
  • potentially, retains its function within the degradative environment of the lysosome and can subsequently traffic out of lysosomes to upregulate its exposure at the cell surface and phagosome
  • ATP gated cation-selective channel, which can be upregulated following nerve injury or stimulation by various cytokines
  • specifically involved in inflammatory-mediated Prostaglandin E2 production and might therefore represent useful therapeutic targets
  • PANX1 hemichannels and P2RX1 and P2RX4 facilitate ATP release and autocrine feedback mechanisms that control Ca(2+) entry and T-cell activation at the immune synapse
  • calcium-permeable cation channels gated by extracellular ATP
  • involved in endothelium-dependent changes in large arterial tone in response to shear stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • cause the release of brain-derived neurotrophic factor (BDNF) from microglia, which is necessary for maintaining pain hypersensitivity after nerve injury
  • interacting with CCL21 (up-regulates microglia P2RX4 expression and initiates neuropathic pain development)
  • cell & other
    REGULATION
    activated by IFNG (IFNG selectively increases P2X4-receptor gene expression, leading to an up-regulation of purinergic signaling in vascular endothelial cells)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Duchenne muscular dystrophy
    constitutional     --over  
    in spinal cord microglia is crucial for tactile allodynia, an untreatable pathological pain reaction occurring after peripheral nerve injury
    Susceptibility to obesity
    Variant & Polymorphism SNP increasing the risk of obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS