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FLASH GENE
Symbol CSRP2 contributors: - updated : 15-03-2007
HGNC name cysteine and glycine-rich protein 2
HGNC id 2470
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   highly
 vesselsaorta   
Digestiveliver    
Nervousbrainforebraincerebral lobefrontal 
 nerve   highly
Respiratoryrespiratory tractlarynx   
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunestellate
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal cysteine-rich LIM/double finger motifs (LIM domains)
  • a glycine-rich repeat
  • HOMOLOGY
    interspecies homolog to Csrp2
    intraspecies homolog to CSRP3
    Homologene
    FAMILY CSRP family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in cellular growth control
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • may be playing a role in the development of the embryonic vascular system
  • playing a protector role in liver fibrosis
  • may have a cytoskeletal role, but as a nuclear protein, actingas a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity
  • genes
  • exert its potent differentiation role through a combinatorial interaction involving DNA-binding transactivators, chromatin remodeling, and histone modifiers
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically associates with other cardiovascular lineage regulators, such as SRF and GATA proteins, to synergistically activate the transcription of Smooth muscle cell target
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS