| basic FUNCTION
| putative growth suppressor gene |
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restriction of tissue growth and reduction of cell size and cell proliferation |
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playing an important role for astrocytes growth control |
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involved in the regulation of centrosome duplication |
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key roles of TSC1/TSC2 in neuronal polarity, suggest a common pathway regulating polarization/growth in neurons and cell size in other tissues (Choi 2008) |
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TSC1-TSC2 complex inhibits MTORC1 and activates MTORC2, which through different mechanisms promotes Akt activation (Huang 2008) |
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with TSC2, function as a heterodimer to inhibit the activity of the mammalian target of rapamycin complex 1 (MTORC1) (Hartman 2009) |
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regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway (Hartman 2009) |
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important role in unfolded protein response and cell survival  |
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important role for the TSC1 gene during GABAergic interneuron development, function, and possibly migration |
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is critical for T-cell anergy, by inhibiting MTOR signaling through both ICOS-dependent and -independent mechanisms |
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regulates likely cell polarity-associated formation of actin fibers through the spatial regulation of Rho family of small GTPases |
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novel function of MTOR in regulating potassium homeostasis, demonstrating that loss of TSC1 and activation of MTOR results in dedifferentiation and dysfunction of the collecting ducts and causes hyperkalemia |
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acts as an important checkpoint for maintaining immune homeostasis by regulating cell fate determination |
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TSC1-MTOR signaling contributes to the brown-to-white adipocyte phenotypic switch |
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TSC1 and TSC2 regulate the activity of small GTPases RHOA and RAC1, stress fiber formation and cell adhesion in a reciprocal manner |
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TSC1 and TSC2 differentially regulate actin stress fiber formation and cell migration, but only TSC2 loss promotes MTOR- and CTRC2-dependent pro-migratory cell phenotype |
