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FLASH GENE
Symbol IL12RB1 contributors: mct - updated : 05-09-2017
HGNC name interleukin 12 receptor, beta 1
HGNC id 5971
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five FBN type III extracellular motifs
  • cytokine-receptor-like modules
  • conserved WSXWS motifs
  • a large cytoplasmic tail containing three tyrosine residues
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • cytokine family of receptors
  • hemopoietin receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I integral transmembrane protein
    basic FUNCTION
  • coordinately regulating IFN-gamma production with antimicrobial humoral response
  • IL12RB1- and STAT3--dependent signals play likely a key role in the differentiation and/or expansion of human IL17-producing T cell populations
  • role of IL12RB1 and IL12RB2 for the expression of inducible nitric oxide synthase (iNOS) and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases
  • is essential for human resistance to multiple intracellular pathogens, including Mycobacterium tuberculosis
  • leukocytes primarily express IL12RB1 in an intracellular form located away from extracellular cytokine
  • in addition to promoting delayed type hypersensitivity (DTH), IL12RB1 also promotes autoimmunity
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • positive control
  • PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with IL12RB2
  • type I transmembrane receptor that is an essential component of the IL12- and IL23-signaling complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pairing with IL23R to form the receptor for IL23A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IL12RB1D
    related resource IL12RB1base: Mutation registry for Interleukin-12 receptor 1 deficiency
    Susceptibility
  • to tuberculosis infection
  • to atopic dermatitis
  • Variant & Polymorphism SNP
  • influencing the course of tuberculosis infection
  • polymorphisms -111A/T and -2C/T were significantly associated with an increased risk of atopic dermatitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS