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FLASH GENE
Symbol SLC25A6 contributors: mct - updated : 31-03-2020
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
HGNC id 10992
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion lymph
at STAGE
physiological period embryo
Text tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
  • three Solcar repeats
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chicken slc25a5
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • adenine nucleotide translocator 3, ADP/ATP translocase
  • has a potential role in Th cell survival and immune cell homeostasis
  • is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis
  • plays a contributive role in camptothecin (CPT)-induced apoptosis through induction of mitochondrial permeability transition pore (MPTP)
  • export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of oxidative phosphorylation (OXPHOS)
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC25A6 is a previously unknown HSPA9 substrate and cell survival/death effector
  • HSPA9 facilitates BRAF-mutant tumor cell survival by suppressing SLC25A6-mediated mitochondrial membrane permeability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    decreased cellular ATP levels, limited cell growth and induced a stress-like response
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS