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FLASH GENE
Symbol MCHR1 contributors: mct/ - updated : 21-12-2011
HGNC name melanin-concentrating hormone receptor 1
HGNC id 4479
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortexfrontal 
 braindiencephalonhypothalamus  
 brainmidbrain   
 brainhindbrainpons  
Reproductivefemale systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • three consensus N glycosylation sites
  • a DRY motif (major contribution of the DRY motif in MCH1R is to govern receptor conformation and G protein coupling/recognition)
  • HOMOLOGY
    intraspecies homolog to stomatostatin-like receptor 1
    Homologene
    FAMILY
  • G protein coupled receptor (stomatostatin receptor) family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • G protein coupled receptor, involved in emotion, memory and sensory perception
  • mediating the effects of MCH (PMCH) on feeding
  • heptahelical integral membrane proteins
  • modulates orexigenic activity of MCH, the corresponding endogenous peptide agonist
  • plays a significant role in regulation of energy balance, food intake, physical activity and body weight
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral
    text neuronal regulation of food consumption
    PATHWAY
    metabolism energetic
    signaling hormonal , signal transduction
    inhibiting adenylate cyclase pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms (
  • cell & other
    REGULATION
    activated by PCMH
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pheochromocytomas, neuroblastomas and ganglioneuroblastomas
    constitutional     --other  
    DNA methylation at MCHR1 is allele-specific, age-dependent, BMI-associated and affects transcription
    Susceptibility
  • to juvenile-onset obesity
  • to bipolar affective disorder and schizophrenia
  • Variant & Polymorphism SNP
  • increasing the risk of juvenile-onset obesity
  • epigenetic regulation contributes to the age- and/or population specific effects reported for MCHR1 in several obesity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    antagonists of MCHR1 function will prove therapeutically useful as anti-obesity agents
    ANIMAL & CELL MODELS
  • lack of ciliary localization of somatostatin receptor type 3 (Sstr3) and melanin-concentrating hormone receptor 1 (Mchr1) in neurons from mice lacking the Bbs2 or Bbs4 gene (altered signaling caused by mislocalization of ciliary signaling proteins underlies the BBS phenotypes, providing a potential molecular mechanism to link cilia defects with obesity)