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FLASH GENE
Symbol MADCAM1 contributors: npt - updated : 09-07-2002
HGNC name mucosal vascular addressin cell adhesion molecule 1
HGNC id 6765
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestine    
Endocrinethyroid    
Lymphoid/Immunespleen    
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal Ig-like domain
  • four cysteine residues forming two intradomain disulfide bridges
  • a serine/proline rich mucin domain
  • HOMOLOGY
    intraspecies homolog to ICAM1,VCAM1
    Homologene
    FAMILY
  • Ig superfamily
  • CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • membrane bound receptor regulating both the passage and retention of leukocytes in mucosal tissues
  • implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for leukocyte B7 integrin (LPAM-1) L selectin, VLA-4 on myeloid cells
  • cell & other
    REGULATION
    activated by requiring NKX2C for expression and function
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS