basic FUNCTION
| being a ligand for TNFRSF9/4-1BB |
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acting as a costimulatory molecule in T lymphocytes |
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involved in the antigen presentation process and in the generation of cytotoxic T cells |
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reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation |
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is required for the optimal CD8 responses in CD8 T cells |
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is thought to be involved in T cell-tumor cell interaction |
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may have a role in activation-induced cell death (AICD) |
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may play a role in cognate interactions between T-cells and B-cells/macrophages |
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is released following leukocyte activation |
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may be an important mediator for maturation of CD11c(+) myeloid dendritic cells |
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may be indicative of the severity and outcome of rheumatoid arthritis |
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involved in reverse signaling in dendritic cells during the initiation of an adaptive immune response, including dendritic cells maturation, migration and, ultimately, antigen-specific T cell differentiation |