basic FUNCTION
| prostate-specific homeobox gene related to prostate development and prostate cancer |
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putatively involved in the differentiation of prostatic tissue (regulation of proliferation of glandular epithelium and formation of ducts) |
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transcription factor critical for normal prostate development and function |
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can behave as a transcriptional repressor |
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required for prostatic epithelial differentiation and suppression of prostate cancer |
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regulating negatively Sp-mediated transcription via the tethering of histone deacetylases and/or by inhibiting the association of Sp proteins with co-activators |
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haploinsufficient cell growth/differentiation regulator |
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androgen-regulated homeobox gene that encodes a tissue-restricted transcription factor, which plays an important role in the differentiation of the prostate epithelium |
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maintains an active DNA damage response at the intra S progression and contributes to the chemotherapeutic resistance of prostate cancer cells to DNA damaging compounds |
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prostate- and testis-specific nucleoprotein with two conserved domains |
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has potentilly a regulatory role for genome maintenance in prostate cells through activation of the DNA damage response |
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NKX3.1-mediated activation of DNA damage response restores the intra S phase arrest upon DNA damage and, consequently, leads to reprogramming of the cells at the G1/S phase transition |
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functions as a “para-transcription factor (PTF),” with the ability to regulate genes and inhibit cell proliferation in a non-cell autonomous manner |
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can penetrate into prostate epithelial cells and translocate into the nucleus |
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PTF function of NKX3.1 is required for its tumor suppressor role in adjacent cells |
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functions to maintain canonical Wnt signaling activity in developing prostate bud tips |
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role as a tumor suppressor gene through direct regulation of the cell cycle and growth/survival pathways |
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encodes a homeobox protein, which transcriptionally regulates oxidative damage responses and enhances topoisomerase I re-ligation by a direct interaction with the ATM protein in prostate cells |
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androgens and NKX3-1 expression regulate the progression of the cell cycle and concurrently activate the DNA damage response (DDR) |
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plays roles in early prostate development and functions as a prostate-specific tumor suppressor |
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plays essential roles in prostate differentiation and prostate cancer |
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NKX3.1-G9a-UTY transcriptional regulatory network is essential for prostate differentiation, and likely disruption of such a network predisposes to prostate cancer |