SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| association of with ER modulates intracellular trafficking and proteasomal degradation of PPP1R15A, and in turn, its ability to modify ER morphology |
basic FUNCTION
| likely involved in apoptosis, cell cycle arrest, DNA damage response |
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cellular stress response protein mediating growth arrest and apoptosis in response to DNA damage, negative growth signals, and protein malfolding |
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cross talk between stress-inducible PPP1R15A and the MTOR signaling pathway plays a critical role in antiviral defense |
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physiological importance of PPP1R15A turnover in protein processing in the endoplasmic reticulum and potential impact of prolonged PPP1R15A expression in human disease as Cystic fibrosis |
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involved in EIF2A dephosphorylation, which is the predominant role of PPP1R15A and PPP1R15B in mammalian development |
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negatively regulates cell migration in wound healing via expression of myosin IIA |
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starvation-induced PPP1R15A suppresses MTOR and, thereby, induces autophagy |
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regulates mTOR signaling pathways for protein synthetic machinery in response to environmental stress |
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functions as a negative regulator of the MTOR pathway by binding to and dephosphorylating TSC2 during starvation period |
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plays an important role in cell protection in mutant huntingtin expressing cells |
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specific EIF2S1 phosphatases, PPP1R15A and PPP1R15B, play crucial roles in the recovery of protein synthesis following the initial insult |
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works to inhibit the proliferation and differentiation of Hematopoietic stem cells (HSCs) or myeloid precursor cells and maintains homeostatic differentiation of neutrophil-lineage cells to avoid early immunological senescence |
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PPP1R15A and its viral orthologs direct specific dephosphorylation of EIF2S1 by interacting with both PP1 and EIF2S1 through independent binding motifs |
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plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis to activate death-associated mechanisms, including ER stress, ROS production and autophagy formation |
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preferentially translated PPP1R15A and constitutively expressed PPP1R15B function to dephosphorylate EIF2S1-Phosphorylated and restore protein synthesis |
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attenuates LPS-induced sepsis and acute tissue injury through suppressing macrophage activation |