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FLASH GENE
Symbol MAGEA3 contributors: mct/npt - updated : 04-06-2020
HGNC name melanoma antigen family A, 3
HGNC id 6801
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineadrenal gland   moderately
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  specific Homo sapiens
 male systemtestis  specific Homo sapiens
Respiratoryrespiratory tractlarynx  moderately
Skin/Tegumentskin   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines myeloma cell lines, melanoma, head and neck squamous cell carcinoma, lung, breast carcinoma
fluid/secretion lymph
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MAGE domain
  • HOMOLOGY
    interspecies homolog to C.elegans Y37E3.15
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • MAGEA3, MAGEA4, MAGEA6,MAGEA8, are expressed in the undifferentiated human embryonic stem (hES) cells and early differentiated embryoid bodies (EBs) cells
  • basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • acting as a tumor antigen
  • functional integrator of diverse signals, including FGFR2 and fibronectin, to modulate cancer progression (Liu 2008)
  • is a cancer-testis antigen whose expression has been demonstrated in a wide array of malignancies including melanoma, brain, breast, lung and ovarian cancer
  • MAGEA1, MAGEA2, MAGEA3, MAGEA5, MAGEA8 genes are crucial in maintaining normal testicular size and protecting germ cells from excessive apoptosis under genotoxic stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • recognized on a melanoma by autologous cytolytic T
  • lymphocytes
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target of the breast cancer risk factor fibroblast growth factor receptor 2 (FGFR2) (Liu 2008)
  • CTCFL positively regulates MAGEA2, MAGEA3, MAGEA4 by binding and inducing a shift to a more open chromatin conformation with promoter demethylation for MAGEA3 or independent of promoter demethylation in case of MAGEA2 and MAGEA4
  • CTCFL binding to the promoters of MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer
  • cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    inhibited by FGFR2 (negatively regulated by FGFR2) (Zhu 2008)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, melanoma, advanced gastric carcinomas and hepatocellular carcinomas, squamous cell carcinoma of head and neck, malignant myeloma
    constitutional     --low  
    results in Tp53 transcriptional induction, also through reciprocal histone acetylation and methylation modifications (Zhu 2008)
    tumoral     --over  
    by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006)
    tumoral     --over  
    GPC3, MAGE1A and MAGEA3 were increased with advanced tumor stage, size, and nodule numbers in Hepatocellular Carcinoma
    tumoral     --over  
    is associated with worse overall survival in undifferentiated pleomorphic sarcoma/myxofibrosarcoma (UPS/MFS)
    tumoral     --over  
    in bladder cancer and especially in tumours of high stage and grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene aberrant methylation patterns of MAGEs CpG islands using methylation-special PCRs may be useful for diagnosis of hepatocellular carcinoma
    Marker
  • MAGEA3, MAGEB4, and ODF4 may be particularly useful for diagnostic and surveillance of bladder transitional cell carcinoma (TCC) in the form of a multi-biomarker panel
  • MAGEA3 expression may serve as an independent marker of poor prognosis in patients with non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may serve as an immunotherapeutic target for Cancer stem cells (CSCs) of bladder cancer
    ANIMAL & CELL MODELS