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FLASH GENE
Symbol MAGEA12 contributors: mct/npt - updated : 25-09-2009
HGNC name melanoma antigen family A, 12
HGNC id 6799
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineadrenal gland   moderately
Reproductivemale systemtestis   
Skin/Tegumentskin   predominantly
cell lineage
cell lines various tumors cell lines (melanoma, lung, breast)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MAGE domain
    • HOMOLOGY
    intraspecies homolog to MAGEA6/MAGEA3
    Homologene
    FAMILY
  • MAGE family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in tumor transformation or aspects of tumor progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary breast cancer in progression
    tumoral     --over  
    in oral squamous cell carcinoma (Mollaoglu 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS