| basic FUNCTION
| transmembrane modulator of Na+, K+-ATPase activity, controling cell excitability by modulating Na+,K+-ATPase activity |
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may contribute to the pathogenesis of other brain disorders linked to aberrant MECP2 expression or activity including schizophrenia and age-related neurodegenerative disease |
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may have been assembled from discrete structural modules through exon shuffling |
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appears to play an important role in fine tuning the gating kinetics of cardiac calcium channels and likely plays an important role in shaping the cardiac action potential and regulating Ca(2+) dynamics in the heart  |
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principal sarcolemmal substrate for protein kinases A and C in the heart, regulating the cardiac sodium pump |
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roles for the Na,K-ATPase subunits, ATP1A1 and FXYD1, during brain ventricle development |
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regulates important ion transporters in the heart and offers a tempting target for development of drugs to treat heart failure. |
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phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation |
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FXYD1 encodes for phospholemman, a regulatory subunit of the cardiac Na(+)/K(+)-ATPase |
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limits Ca(2+) influx in cardiac myocytes by reducing maximal L-type Ca(2+) current (ICa) and accelerating voltage-dependent inactivation |
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FXYD1 plays a role in regulating AQP2 retention in apical membrane, and this involves transfers between raft-like membrane domains in endosomes and plasma membranes |
