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FLASH GENE
Symbol STK3 contributors: mct - updated : 16-12-2016
HGNC name serine/threonine kinase 3
HGNC id 11406
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Nervousbrain    
Respiratorylung   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal catalytic domain
  • SARAH domains acting as a platform to mediate homodimerization and hetero-interaction with a range of adaptors including RASSFs and Salvador, which also possess SARAH domains (hetero-interaction with RASSF5 are required for full activation of STK3 and therefore apoptotic functions in T cells)
  • conserved C-terminal coiled-coil domains
  • HOMOLOGY
    interspecies homolog to yeast Ste20
    homolog to murine Stk3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine threonine kinase
  • playing a role in the response to environmental stress
  • phosphorylates and activates both LATS1 and LATS2
  • with STK4, are activated in mitosis and catalyze the mitotic phosphorylation of MOBKL1A/MOBKL1B
  • serves as a hub to integrate biological outputs of the RAF1 and AKT pathways
  • STK3-, FRY-, and MOB2-mediated activation of STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells
  • STK3, STK4 control Rho GTPase activation and the migratory responses of single-positive (SP) thymocytes
  • STK3/STK4 are required for proper cardiac lineage cell development and teratoma formation
  • STK3, STK4 are key players in mammalian Hippo pathway
  • STK3/STK4 regulate potentially placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and STK3/STK4 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forming an active complex with RASSF2
  • SAV1 and STK3 heterodimerize through their SARAH domains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SAV1 (SAV1 can bind to, and be phosphorylated by STK3, and the stabilizing effect of STK3 on SAV1 requires its interaction with SAV1 but is probably not due to phosphorylation of SAV1 by STK3)
  • binding partner of RASSF2 (STK3 and RASSF2 form an active complex, in which RASSF2 is maintained in a phosphorylated state and protects STK3 from degradation and turnover)
  • STK3 and the scaffold protein Salvador (SAV1), directly interact with NEK2 and regulate its ability to localize to centrosomes, and phosphorylate CEP250 and rootletin
  • RASSF1 interacts with and activates STK3/STK4 kinases by preventing their dephosphorylation
  • MST2-mediated phosphorylation of four residues within SAV1 may be important in the induction of cell death by the MST pathway
  • STK3/STK4 timulated the binding of SAV1 to PPARG, a transcription factor that plays a key role in adipogenesis
  • ABL1 is a novel upstream activator of STK3 suggesting that the conserved ABL1-MST signaling cascade plays an important role in oxidative stress-induced neuronal cell death
  • ADRBK1 plays a central role in mitogen-promoted centrosome separation most likely via its ability to phosphorylate STK3
  • RASSF5 can act as an inhibitor or a potential positive regulator of STK3, depending on whether it binds to STK3 before or after activation-loop phosphorylation
  • physical interaction of BCL2 with SAV1 was correlated with proteasomal degradation of SAV1 and STK3 proteins
  • cell & other
    REGULATION
    activated by cell stress
    RASSF1 (activates STK3 and STK4 by promoting their autophosphorylation and phosphorylation of the downstream LATS1 kinase)
    inhibited by RASSF6 (RASSF6 inhibited MST2 activity to antagonize Hippo signaling)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS