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FLASH GENE
Symbol AANAT contributors: mct - updated : 17-01-2009
HGNC name arylalkylamine N-acetyltransferase
HGNC id 19
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina    Homo sapiens
cell lineage
cell lines retinoblastoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • acetyltransferase family
  • AANAT subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • penultimate step in melatonin synthesis, controlling its circadian rhythm production
  • modulating the function of the circadian clock in the supra optical nucleus and influencing activity and sleep
  • catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis
  • controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controlling the circadian rhythm of melatonin production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to delayed sleep phase syndrome
    Variant & Polymorphism SNP significantly associated with the delayed sleep phase syndrome
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS