motifs/domains
| a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich, basic charged globular module, interacting with MPP1 |
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a spectrin-actin-binding domain (SABD) |
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a glycophorin/calmodulin binding domain |
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a C terminal region |
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a spectrin-actin-binding domain |
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a protein-saccharide modification structure |
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a nuclear localization signal (NLS) |
basic FUNCTION
| critical for the membrane-associated cytoskeleton structure of erythocytes, playing a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction |
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regulating in central neurons, the stabilization of AMPA receptors on the neuronal surface at the postsynaptic density |
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responding and participating in reorganization of membrane-cytoplasmic interactions |
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makes crucial contributions to the structural integrity of centrosomes and mitotic spindles which normally enable mitosis and anaphase to proceed with the coordinated precision required to avoid pathological events |
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promote the mechanical stability of plasma membranes by interaction with the cytoskeletal proteins spectrin and actin and required for the cell surface expression of a number of transmembrane proteins |
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role in modulating the functional properties of several cardiac ion transporters with consequences on cardiac electrophysiology and with possible significant roles during normal cardiac function and disease |
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its expression involves transcriptional regulation coupled with a complex splicing regulatory network |
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required for the stable cell surface accumulation of a number of erythrocyte membrane proteins |
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have roles in the accumulation of at least three classes of ion channel |
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EPB41, EPB41L1, EPB41L2 proteins are differentially compartmentalised in the heart, and they form specific complexes with proteins central to cardiomyocyte Ca(2+) metabolism |
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regulates SLC9A1 activity through a direct protein-protein interaction that can be modulated by intracellular pH and Na(+) and Ca(2+) concentrations |
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adapter that link actin-based cytoskeleton to plasma membrane proteins |
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component of cell membrane cytoskeleton, that plays a part in erythrocyte shape and deformability |