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FLASH GENE
Symbol FGF12 contributors: mct - updated : 21-11-2016
HGNC name fibroblast growth factor 12
HGNC id 3668
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartventricle    Homo sapiens
Nervousbrain   predominantly Homo sapiens
 spinal cord    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • clusters of basic residues potentially acting as nuclear localization signals (NLS)
  • can be internalized into cells depending on a CPP domain (CPP-C), at the C-terminal region, that can play a role in delivering other polypeptides into cells as a CPP (cell-penetrating peptide)
  • not only lacks classical signal sequences but also fails to activate FGFRs
  • HOMOLOGY
    intraspecies homolog to fibroblast growth factor 12
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF11 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • able to inhibit radiation-induced tissue damage like other FGFs
  • intracellularly suppresses radiation-induced apoptosis in mast cells independently of MAPK8IP2
  • plays an intracellular role in the inhibition of radiation-induced apoptosis
  • can be internalized into cells to play a role in physiological events
  • may also be secreted from mast cells via other unknown pathways
  • potential radioprotector that could exert therapeutic effects on radiation damage
  • FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
  • FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
  • can protect the intestine against radiation-induced injury through its internalization, independently of FGFRs
  • strongly induced the quiescent and contractile Vascular smooth muscle cells (VSMCs) phenotypes and directly promoted VSMC lineage differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component unknown
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can bind heparin with high affinity, as for other FGFs, and a heparin-binding site of FGF12 seems to be similar to that of other FGFs
  • could bind to the C terminus of the cardiac voltage-gated sodium channel to modulate its properties
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE47
    Susceptibility
  • for Kashin-Beck disease (KBD)
  • Variant & Polymorphism other
  • most significant association signal was observed at rs1847340 for KBD
  • Candidate gene
  • candidate for Brugada syndrome
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousvascularischemic injury
    could be a new therapeutic target for treating restenosis and atherosclerosis
    ANIMAL & CELL MODELS