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FLASH GENE
Symbol ZAN contributors: mct - updated : 20-11-2010
HGNC name zonadhesin
HGNC id 12857
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three MAM domains
  • four VWFD domains
  • one EGF-like domain
  • mono polymer oligo
    HOMOLOGY
    interspecies ortholog to murine Zan
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • encoding a sperm membrane protein that binds the zona pellucida of the egg in a species-specific manner
  • involving in gamete recognition and signaling
  • ability to bind directly and in a species-specific manner to native zona pellucida
  • acrosomal protein involved in sperm-zona pellucida recognition
  • zona pellucida adhesion molecule that confers species specificity to sperm-egg adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the zona pellucida of the egg
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS