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FLASH GENE
Symbol TADA2A contributors: mct/npt - updated : 09-12-2009
HGNC name transcriptional adaptor 2A
HGNC id 11531
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SWIRM domain, having a functional role in chromatin remodeling
  • HOMOLOGY
    interspecies homolog to yeast ADA2 transcriptional adaptor
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • enhancing the initial rate of RNA polymearse II mediated transcription
  • with TADA3, are crucial cofactors of beta-catenin likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GCN5L2
  • physically interact with CTNNB, and the interaction is mediated through Armadillo repeats 6 through 12 and the C-terminal transactivation domain of beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS