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FLASH GENE
Symbol PLAG1 contributors: mct/npt - updated : 17-04-2010
HGNC name pleiomorphic adenoma gene 1
HGNC id 9045
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 pharynx    
 salivary gland    
Endocrineneuroendocrinepituitary   
Gustatory (taste)earinnercochlea  
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandular  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung, liver, kidney, rain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven zinc fingers, C2H2 type
  • serine-rich C terminus
  • two putative nuclear localization signals (NLS)
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated in the molecular pathogenesis of hepatoblastoma
  • transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins, involved in transcriptional induction of ABCC6 (Ratajewski 2008)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NLS1 of PLAG1 and during its nuclear import
  • cell & other
    REGULATION
    activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with beta catenin in adenomas with translocation t(3;8)(p21;q12), TCEA1, with t(3;8)(p21;q12) in salivary adenomas
    tumoral       gain of function
    activated by 'promoter-swapping'in Lipoblastoma (Ropke 2007)
    tumoral fusion      
    CHCHD7-PLAG1 fusions in pleomorphic salivary gland adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS