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FLASH GENE
Symbol SLC7A2 contributors: mct/npt/pgu - updated : 31-10-2013
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
HGNC id 11060
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbraindiencephalonhypothalamus highly Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainbasal nucleicaudate nucleus   Homo sapiens
 plexus choroid     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Endocrineislet cell (alpha,beta...)
Nervousastrocyte Homo sapiens
Nervousneuron Homo sapiens
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
    • HOMOLOGY
    interspecies homolog to murine Slc7a2
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • cationic amino acid transporter (CAT) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • SLC7A1 mediated L-arginine influx, is essential for both inducible nitric oxide synthase and arginase enzyme activities, which in turn modulate proliferation and differentiation of human epidermal skin cells
  • via arginine transport, plays a critical regulatory role in classical or alternative activation of macrophages
  • by controlling NOS2 and arginase activity, functions as a potent regulator of immunity
  • is a regulator of fibrotic responses in the lung
  • is an important regulator of the immune response during H. pylori infection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FRAP1 (FRAP1 activity is associated with the repression of SLC7A2 expression at mRNA and protein level)
  • DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • a single-nucleotide variation in the first intron of the SLC7A2 gene (IVS1-1713 A > G) associated to infantile encephalopathy with severe infantile anorexia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cat2(-/-) mice are significantly more susceptible to the Th1-inducing pathogen Toxoplasma gondii