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FLASH GENE
Symbol NAP1L1 contributors: mct/npt - updated : 29-03-2014
HGNC name nucleosome assembly protein 1-like 1
HGNC id 7637
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Hearing/Equilibriumear   moderately
Lymphoid/Immunetonsils   predominantly
Nervousbrain   specific
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion moderately in lymph
at STAGE
physiological period fetal
Text highly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential nuclear localization signal (NLS)
  • three clusters of acidic residues and other motifs (acidic domains probably involved in the interaction with histones)
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Nap1l1 (98.2 pc)
    homolog to murine Nap1l1 (98.2 pc)
    intraspecies paralog to NAP1L*
    Homologene
    FAMILY
  • nucleosome assembly protein (NAP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text
  • nucleocytoplasmic shuttling protein (Calvert 2008)
  • localized mainly to the cytoplasm and a minor population of them was suggested to be in the nucleus (Okuwaki 2010)
  • basic FUNCTION
  • may be involved in modulating chromatin formation
  • contributing to regulation of cell proliferation
  • participating in DNA replication
  • cofactor for the import of histones H2A and H2B, a chromatin assembly factor and a mitotic factor involved in regulation of bud formation (Calvert 2008)
  • cooperates with EP300 in eviction of the acetylated histones from the chromatin template (Sharma 2008)
  • promotes nucleosome assembly by eliminating nonnucleosomal histone DNA interactions (Andrews 2010)
  • histone chaperone protein suspected to be involved in the dynamical regulation of the histone H2A-H2B hetero-dimer (Okuwaki 2010)
  • with NAP1L4 mediated nucleosome formation (Okuwaki 2010)
  • possess a significantly greater nucleosome disassembly activity than NAP1L4, suggesting that NAP1L1 and NAP1L4 may play distinct roles in the regulation of histone dynamics (Okuwaki 2010)
  • is required for cohesin release and sister chromatid resolution during mitosis
  • NAP1L1 binding to cohesin is cell-cycle regulated and increases during G2/M phase
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, chromatin organization, remodeling
    nucleotide, replication
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibiting acetylation of core histones by EP300
  • interacting with TTLL10 (Ikegami 2008)
  • balanced antagonism between NAP1L1 and PP2A controls cohesin dissociation during mitosis
  • through regulating NAP1L1, PRDM8 inhibits PI3K/AKT/mTOR signaling in Hepatocellular carcinoma (HCC)
  • cell & other
    REGULATION
    Other prenylated
    phosphorylation by CSNK2A1 appears to regulate its localization and is required for normal progression through S phase (Calvert 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS