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FLASH GENE
Symbol ELK1 contributors: mct - updated : 26-11-2014
HGNC name ELK1, member of ETS oncogene family
HGNC id 3321
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   moderately
Reproductivefemale systemuteruscervix highly
 male systemprostate  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region (AAs 132) in the ETS domain responsible for ELK-1 dimerization in the cytosol
  • a domain (Box B) mediating the interaction with serum response factor (SRF)
  • a domain (Box C) regulating transcriptional activation
  • many putative microtubule binding domains, with the strongest binding prediction in AAs 314-325
  • a proline-rich hydrophobic motif (AAs 187216) between the B and S domains that could be the recognition element for E3 ligases
  • conjugated PhosphoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to rattus Elk1
    ortholog to murine Elk1
    homolog to C. elegans lin-1
    intraspecies homolog to ets protooncogene 1
    Homologene
    FAMILY
  • divergent member of the winged helix-turn-helix superfamily
  • ETS family of transcription factors
  • ternary complex factor (TCF) subfamily
  • CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text anchored to neuronal microtubules in resting or unstimulated cells, and upon stimulation is phosphorylated, which relocalizes phospho-ELK1 to the nucleus in neurons
    basic FUNCTION
  • stimulating transcription
  • decreasing cell viability upon its association with the mitochondrial permeability transition pore complex
  • involved in the regulation of immediate-early genes such as c-fos upon mitogen activation, and thus commonly implied in cell proliferation
  • important for synaptic plasticity and interact with microtubules
  • uses different DNA binding modes to regulate functionally distinct classes of target genes
  • ELK1 and GABPA ultimately control the same biological process, but they do so by regulating different cohorts of target genes associated with cytoskeletal functions and cell migration control
  • directs selective and sustained gene induction that is a substantial and critical component of growth signaling by AR in prostate cancer cells
  • role of ELK1 in the differences between pluripotent stem cells with distinct X chromosome inactivation statuses.
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • being a nuclear target for the ras-raf-MAPK signaling cascade
  • CENTA1-RAS-ELK1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to APP in hippocampal neurons
  • a component
  • forming a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element
  • PTK2/ELK1 complex is found, mainly, in the cytoplasm, near the nuclear membrane periphery, raising the possibility that ELK1 may have alternative extranuclear function
  • on mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1
  • associated with the mitochondrial permeability transition pore complex
  • among the SENPs, ELK1 preferentially forms a complex with SENP1
  • INTERACTION
    DNA binding to serum response element of c-fos
  • binding to purine-rich DNA sequences
  • RNA
    small molecule
    protein
  • a ternary complex factor 1
  • SRF transcription factor
  • can biochemically interact with microtubules
  • binding-protein partner for PTK2, a finding that significantly broadens the potential functioning of PTK2 and ELK1
  • binding of ELK1 to the SERPINE1 promoter and ELK1 phosphorylation on the Ets binding site is EGF-dependent
  • SMN1 is a novel target of ELK1, and the ETS motifs in the SMN1 promoter are involved in this regulation
  • RUNX1 and ELK1, two proteins with essential functions in hematopoiesis, regulate MECOM in acute myeloid leukemia
  • ELK1 activated KATNB1 promoter
  • FBXO25 interacts and mediates ubiquitination and proteasomal degradation of the ELK1 protooncogene regulator
  • cell & other
    REGULATION
    activated by several mitogen-activated protein kinases (MAPKs)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP cosegragation of T108A with mental retardation
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    CENTA1-RAS-ELK1 signaling pathway is a new pharmacological target for Alzheimer disease
    ANIMAL & CELL MODELS