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FLASH GENE
Symbol SLC25A5 contributors: mct - updated : 22-05-2013
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
HGNC id 10991
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiensAdultmRNA
Nervousbrainlimbic systemhippocampus highly Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiensAdultmRNA
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three tandemly repeated mitochondrial carrier protein domains (SOLCAR repeats)
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Slc25a5
Homologene
FAMILY solute carrier family 25, mitochondrial, adenine nucleotide
CATEGORY transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
text
  • imports glycolytically produced ATP into the mitochondria
  • basic FUNCTION
  • ADP/ATP translocase, oxidative phosphorylation (OXPHOS), catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane
  • playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth
  • linked to the rate of glycolytic metabolism, is an important indicator of carcinogenesis
  • not pro-apoptotic and may therefore contribute to carcinogenesis
  • is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text energy transfer
    PATHWAY
    metabolism energetic , metal
    signaling
    a component
  • complexing with cyclophilin D (PPID and PPIF) at the inner mitochondrial membrane and voltage dependent anion selective channel(s) at the outer membrane, to form the mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NF1 (nuclear factor 1) binds to two upstream elements of SLC25A5 promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts
  • interacts with Fe-S apoproteins and MMS19 in the cytosolic Fe-S cluster assembly complex but not with the individual proteins
  • cell & other
    REGULATION
    repressed by nuclear factor-1 in growth-arrested human diploid cells
    ASSOCIATED DISORDERS
    corresponding disease(s) HARTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in patients with non-syndromic ntellectual disability (ID) plus some additional features
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for cancer therapy based on molecular targeting
  • Marker
    Therapy target
    ANIMAL & CELL MODELS