basic FUNCTION
| may regulate epithelial morphogenesis during mammalian kidney development, and plays a role in cellular migration |
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can modulate the cAMP-mediated signal transduction pathway by preferential binding to the regulatory subunit type I (RIalpha) of cAMP-dependent protein kinase and by phosphorylating the type II regulatory subunit in the absence of cAMP |
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stimulates epithelial branching morphogenesis by activating cell migration and support a role for this kinase in the regulation of nephrogenesis and of collecting system development in the fetal kidney |
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with SMAD6 are required for PMA-induced cell attachment and spreading |
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signal-transduction protein required for macrophage differentiation |
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can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for PKD1 |
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cAMP-dependent kinase, regulator of epithelial morphogenesis during kidney development |
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stimulates endothelial cell proliferation, migration, and vascular-like structure formation, which are the three essential processes for angiogenesis |