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FLASH GENE
Symbol ARSF contributors: - updated : 16-05-2006
HGNC name arylsulfatase F
HGNC id 721
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   lowly
Reproductivemale systemprostate  lowly
 male systemtestis  lowly
Urinarykidney   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 19 aa signal peptide (2.2 kda)
  • isoforms Precursor a 571 aa matude peptide (63.7 kda)
    HOMOLOGY
    intraspecies homolog to ARSC1
    Homologene
    FAMILY
  • sulfatase family
  • arylsulfatase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • secreted
  • basic FUNCTION
  • playing an essential role for the correct composition of bone and cartilage matrix
  • acting as a sulfuric ester hydrolase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ca2+ (a ion per subunit)
  • protein
    cell & other
    REGULATION
    inhibited by not inhibited by warfarin
    Other escaping inactivation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS