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FLASH GENE
Symbol HCFC1 contributors: mct/npt/pgu - updated : 07-03-2017
HGNC name host cell factor C1 (VP16-accessory protein)
HGNC id 4839
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouth   moderately
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland highly
 female systemovary  highly
 female systemuteruscervix moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion predominantly in lymph
at STAGE
physiological period embryo
Text
  • highly expressed during embryonic brain development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • octamer sequence (SiSa) known to bind YY1
  • five Kelch repeats, (a Kelch domain at the N terminus of HCF-1N)
  • a fibronectin-like motif
  • six HCF repeats, each of which contains a highly specific cleavage signal
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor heterodimer of HCF-1N and HCF-1C, which are produced by proteolytic processing of a large precursor protein
    HOMOLOGY
    interspecies homolog to rattus Hcfc1 (94.2 pc)
    homolog to murine Hcfc1 (94.3 pc)
    Homologene
    FAMILY
  • host cell factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text localized to the Golgi apparatus in unstimulated neurons, a unique location for a transcriptional coactivator
    basic FUNCTION
  • playing a role in the positive regulation of progression through cell cycle
  • involved in the regulation of protein complex assembly
  • induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation
  • cellular transcriptional coactivator critical for mediating the regulated expression of the immediate-early genes of the herpes simplex virus type 1 and varicella-zoster virus
  • important component of the viral latency-reactivation cycle that is regulated by association with a component that is distinct from the identified HCFC1 interaction factors
  • requirements during M-phase and G0/G1-S phase progression
  • required for stabilizing OGT in the nucleus
  • potent regulator of embryonic neural development
  • unusual transcriptional regulator that undergoes a process of proteolytic maturation to generate N- (HCF-1(N)) and C- (HCF-1(C)) terminal subunits noncovalently associated via self-association sequence elements.
  • functional relationship between HCFC1 and cobalamin metabolism
  • transcriptional co-regulator playing critical roles in promoting cell cycle progression in diverse cell types, and in maintaining self-renewal of embryonic stem cells
  • represents a novel transcriptional regulator required for maintaining pancreatic beta-cell function
  • functions as a direct coregulator of E2F proteins, facilitating the expression of genes necessary for cell proliferation
  • HCFC1 function is required for both extraembryonic and embryonic development
  • roles for HCFC1 in early embryonic cell proliferation and development
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with OCT1, POU2F1
  • O-glycosylated
  • heterodimer of HCF-1N and HCF-1C, which are produced by proteolytic processing of a large precursor protein (HCF-1N is essential for G1 phase progression, whereas HCF-1C is important for proper cytokinesis)
  • assembled BAP1/HCFC1/YY1 complex acts to induce the activation of COX7C or other target genes
  • THAP11/ZNF143/HCFC1 complex is a critical component of the transcriptional regulatory network governing cell proliferation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to YY1 transcription factor
  • binding to herpes simplex virus acidic transactivator protein VP 16
  • binding to the leucine-zipper protein CREB3
  • interacting with E2F1 (E2F1 HCFC1-binding site can modulate both up and down the ability of E2F1 to induce apoptosis indicating that HCFC1 association with E2F1 is a regulator of E2F1-induced apoptosis)
  • binds directly to THAP11 (association with HCFC1 suggests an epigenetic mechanism of gene repression in pluripotent cells)
  • associating with THAP1 and OGT to the RRM1 promoter during endothelial cell proliferation
  • BAP1 is a nuclear deubiquitinase known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCFC1 transcriptional co-factor
  • large proportion of the signaling enzyme OGT is complexed with HCFC1 and this interaction is essential for HCFC1 cleavage
  • binding of BAP1 to HCFC1 is likely to be important for BAP1-mediated suppression of RCC development
  • coregulator of the zinc-finger transcription factor THAP11 . directly associates with YY1, and through the interaction of YY1 with MECP2, it regulates mitochondrial adenine nucleotide translocase SLC25A4 and thus might contribute to the pathology of Rett syndrome
  • crucial role of HCFC1 in cell-cycle regulation and particularly in cell growth is supported by its interaction with the deubiquitinating enzyme BAP1
  • KMT2E can associate with the cell cycle regulator "host cell factor" (HCFC1)
  • role for HCFC1 in transcriptional regulation of MMACHC
  • distinct OGT-binding sites in HCFC1 promote proteolysis
  • serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators
  • interaction between ZNF143 and HCFC1, a protein that regulates expression of the Cbl trafficking enzyme MMACHC
  • CREB3 interaction with cell cycle regulator HCFC1
  • cell & other
    REGULATION
    Other regulated by BAP1 (BAP1 helps to control cell proliferation by regulating HCFC1 protein levels and by associating with genes involved in the G(1)-S transition)
    protein glycosylation and HCFC1 cleavage occur in the same active site
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX3 , MMACHX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    disrupt neuronal and neural progenitor cells of the developing brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS