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FLASH GENE
Symbol KAL1 contributors: mct - updated : 01-07-2006
HGNC name Kallmann syndrome 1 sequence
HGNC id 6211
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Olfactoryolfactory bulb    
Reproductivemale systemprostate   
 male systemtestis  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousmitral cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, bulb, neuroretina and kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich motif
  • a four disulfide core domain similar to structures described in serine protease inhibitors and neurophysin
  • four fibronectin type III repeats typical of extracellular matrix molecule and potentially involved in processes of neuronal migration and axonal guidance
  • one WAP type domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text basement membrane and interstitial matrix
    basic FUNCTION
  • involved in olfactory axon targeting promoting axonal
  • branch formation from olfactory bulb output neurons
  • playing a direct action on the migratory activity of the GnRH neurons
  • co-ligand modulator of FGFR signaling that amplifies and specifies FGFR1 signaling responses during nervous system development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text axon guidance
    PATHWAY
    metabolism
    signaling sensory transduction/olfaction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heparin binding protein
  • interaction between anosmin-1 and the FGFR1-FGF2-heparan sulfate complex, leading to amplified responses in the FGFR1 signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL1 , DELXPM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS