Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SYP contributors: mct - updated : 13-11-2014
HGNC name synaptophysin
HGNC id 11506
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine duodenumBrunners gland  Homo sapiens
Nervousbrainforebraincerebral cortexfrontal cortex  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivegoblet Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text midgestation->adult
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments (TM4)
  • intra-cytoplasm N and C termini
  • calcium-binding activity domain in the cytoplasmic tail
  • MARVEL-domain
  • mono polymer homomer , tetramer , hexamer
    HOMOLOGY
    Homologene
    FAMILY
  • synaptophysin/synaptobrevin family
  • MARVEL-domain family of integral membrane proteins
  • CATEGORY structural protein , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • integral synaptic vesicle (SV) protein
  • basic FUNCTION
  • may be involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane
  • involved in membrane apposition and vesicle-trafficking events
  • may be playing a role in fusion and recycling that is regulated by known interactions with the SNARE machinery
  • Ca2+ binding glycoprotein widely found in presynaptic membrane and vesicles
  • critical for regulating neurotransmitter release and synaptic plasticity, a process thought to be disrupted in schizophrenia
  • is potentially involved specifically in the response to a nocturnal light pulse occurring in the early night
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VAMP2 (association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis)
  • cell & other
    REGULATION
    Other regulated by REST
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX96
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in mental retardation
    Susceptibility to attention deficit hyperactivity disorder
    Variant & Polymorphism SNP
  • associated to attention deficit hyperactivity disorder
  • interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Syp, a modulator of neurotransmitter release, are defective in delaying clock phase
  • from mice 9 months old on, a progressive decrease of the presence of SYP was found under Inner hair cells and outer (OHCs) hair cells rows starting at the basal coil and reaching the apical coil in the oldest mice