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FLASH GENE
Symbol USP11 contributors: shn - updated : 06-11-2017
HGNC name ubiquitin specific protease 11
HGNC id 12609
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Cys box, His box, Asp and KRF domains
  • HOMOLOGY
    interspecies ortholog to Usp11, Mus musculus
    ortholog to Usp11, Rattus norvegicus
    Homologene
    FAMILY deubiquitin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text primarily localized in the nucleus of non-dividing cells
    basic FUNCTION
  • deubiquitinating enzyme controling many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction
  • USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR
  • USP11 is a critical determinant of mammary tumor initiation and progression
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RanGTP-associated protein RanBPM
  • breast cancer 2, early onse, BRCA2
  • Polycomb repressive complex 1, PRC1; melanoma nuclear protein 18, MEL18; BMI1 polycomb ring finger oncogene, BMI1
  • USP11 is an interactor of SMAD7, enhances TGFB1 signalling and can override the negative effects of SMAD7
  • USP11 is a functional interactor of RNF4, and USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counteract RNF4
  • USP11 is a unique deubiquitylation enzyme for gammaH2AX
  • XIAP is a target for USP11 and stabilization of XIAP due to its deubiquitylation by USP11 leads to the inhibition of cell anoikis and apoptosis, which in turn promotes tumorigenesis
  • USP11 controls VGLL4 protein stability by promoting its deubiquitination
  • EIF4B is a bonafide substrate of USP11, which stabilizes and enhances EIF4B activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    USP11 depletion results in inhibition of TGFB1-induced epithelial to mesenchymal transition
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS