protein
| RanGTP-associated protein RanBPM |
|
breast cancer 2, early onse, BRCA2 |
|
Polycomb repressive complex 1, PRC1; melanoma nuclear protein 18, MEL18; BMI1 polycomb ring finger oncogene, BMI1 |
|
USP11 is an interactor of SMAD7, enhances TGFB1 signalling and can override the negative effects of SMAD7 |
|
USP11 is a functional interactor of RNF4, and USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counteract RNF4 |
|
USP11 is a unique deubiquitylation enzyme for gammaH2AX |
|
XIAP is a target for USP11 and stabilization of XIAP due to its deubiquitylation by USP11 leads to the inhibition of cell anoikis and apoptosis, which in turn promotes tumorigenesis |
|
USP11 controls VGLL4 protein stability by promoting its deubiquitination |
|
EIF4B is a bonafide substrate of USP11, which stabilizes and enhances EIF4B activity |