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FLASH GENE
Symbol FAM3A contributors: mct - updated : 06-07-2015
HGNC name family with sequence similarity 3, member A
HGNC id 13749
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselartery  highly Rattus norvegicus
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
 liver   moderately
Endocrinepancreas   moderately
Reproductivefemale systemovary  highly
 female systemuteruscervix highly
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialbarrier/liningendothelium  
Muscularsmoothvessel   Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
hydrophobic leader sequence
HOMOLOGY
interspecies homolog to murine Oit1
Homologene
FAMILY
  • 2-19 family
  • FAM3 family
  • cytokine-like gene family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • secreted
  • mainly localized in the mitochondria, where it increases adenosine triphosphate (ATP) production and secretion in cultured hepatocytes
  • subcellularly located in mitochondria, where it affects ATP production and release
  • basic FUNCTION
  • plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PIK3CA-AKT1 signaling pathway by way of a Ca(2+) /CALM1-dependent mechanism
  • FAM3A activates AKT1 in a PIK3CA-dependent manner, but induces ERK1/2 activation independent of PIK3CA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel target gene of PPARG (upregulation of FAM3A by PPARG activation is correlated with increased AKT1 level in liver cells)
  • promotes proliferation and migration of VSMCs via P2RY1 receptor-mediated activation of AKT1 and ERK1/2 pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS