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FLASH GENE
Symbol CALB1 contributors: mct/npt - updated : 03-06-2015
HGNC name calbindin 1, 28kDa
HGNC id 1434
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
 stomach    
Nervousbrain    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six EF-hand Ca2+ binding motifs
  • four calcium binding sites
  • HOMOLOGY
    interspecies homolog to murine Calb1
    Homologene
    FAMILY
  • calbindin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • vitamin D dependent calcium binding protein 1
  • acting not only as a potent calcium buffer but also as a calcium sensor
  • calcium-binding protein that widely is expressed in neurons
  • CALB1, CALB2, PVALB, regulate presynaptic inner hair cells (IHCs) function for metabolically efficient sound coding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting IMPA1 in spines and dendrites of cerebellar Purkinje neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Parkinson disease (associated with PD independently of SNCA)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS