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FLASH GENE
Symbol C5 contributors: mct/npt - updated : 02-05-2013
HGNC name complement component 5
HGNC id 1331
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunetonsils    
Nervousbraindiencephalonhypothalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one anaphylatoxin-like domain
  • one NTR domain
  • secondary structure an alpha 2
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Hc
    ortholog to rattus c5
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • complement component 5, initiating, after activation, the assembly of the late complement components C5-C9 into the membrane attack complex
  • activation of the complement cascade and formation of C5a may play a role in the onset of acute coronary events by induction of MMPs in atherosclerotic lesions (
  • its activation elicits proteolytic cascades which eventually results in the cleavage of the C5 protein into two fragments, C5a and C5b
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text chemotaxis C5a
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component 5 associating with the late components to form the membrane attack complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C5b, the C345C domain of C5 and the FIMs of C7, which mediates reversible binding of C5 to C7 in solution, plays an essential role in MAC (membrane attack complex) formation and complement lytic activity
  • thrombin and C5 convertase are invariant partners, enhancing the terminal pathway via the generation of newly uncovered C5 intermediates
  • small anaphylatoxin C5a induces a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2, while the large C5b fragment nucleates formation of the membrane attack complex capable of killing susceptible pathogens by the formation of a pore structure
  • cell & other
    REGULATION
    inhibited by inactivated (cleaved) in the classical pathway by the complex C4b,C2a,C3b and in the alternative pathway by the complex C3b,BF
    ASSOCIATED DISORDERS
    corresponding disease(s) C5
    related resource C5base - Mutation registry for C5 deficiency
    Susceptibility
  • to hepatic fibrosis
  • to rheumatoid arthritis
  • to adverse cardiovascular outcome in male patients with carotid atherosclerosis
  • Variant & Polymorphism other
  • a common genetic variant at the TRAF1-C5 locus is associated with an increased risk of anti-CCP-positive rheumatoid arthritis (Plenge 2007)
  • C5 rs17611 GG genotype is associated with increased C5a plasma levels and represents a risk factor for adverse cardiovascular outcome in male patients with carotid atherosclerosis
  • Candidate gene
    Marker
  • C5 fragment levels in cerebrospinal fluid (CSF) of patients with bacterial meningitis correlated with several clinical indicators of poor prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    C5-specific monoclonal antibodies could be a promising new antiinflammatory adjuvant therapy for pneumococcal meningitis
    ANIMAL & CELL MODELS
  • C5a receptor-deficient mice with pneumococcal meningitis had lower CSF wbc counts and decreased brain damage compared with WT mice