basic FUNCTION
| regulator of photoceptor development and function |
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signaling by RA via RA receptors regulates the expression of NRL, providing a framework for delineating early steps in photoreceptor cell fate determination |
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regulator of rhodopsin expression synergistically with Crx |
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basic motif leucine zipper transcription factor that regulates the expression of several rod-specific genes, including rhodopsin and cGMP phosphodiesterase beta-subunit, in synergy with other transcription factors |
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regulates the expression of several rod-specific genes such as rhodopsin and cGMP phosphodiesterase beta-subunit |
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is essential for rod photoreceptor specification in the mammalian retina as its loss of function converts rod precursors to functional cones |
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critical for rod versus cone photoreceptor cell fate choice during retinal development and acts as a molecular switch to produce rods from postmitotic precursors |
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essential transcription factor for cell fate specification and functional maintenance of rod photoreceptors in the mammalian retina |
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is a critical determinant of rod photoreceptor cell fate and a key regulator of rod differentiation |
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transcription factor, modulating rod photoreceptor differentiation by activating rod-specific target genes |
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activated rhodopsin and PPP2R5C transcription by recruiting KAT5 to promote histone H3/H4 acetylation |
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is essential for rod photoreceptor development and functional maintenance in the mammalian retina |