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FLASH GENE
Symbol DDC contributors: mct/npt - updated : 21-04-2010
HGNC name dopa decarboxylase (aromatic L-amino acid decarboxylase)
HGNC id 2719
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
Respiratorylung   highly
Urinarykidney   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • pyridoxal-dependent decarboxylase conserved domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • pyridoxal-dependent aminotransferase superfamily
  • group II decarboxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • aromatic L-amino acid decarboxylase, required for the synthesis of dopamine and serotonine
  • pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine (Kokkinou 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients (Avgeris 2008)
    Susceptibility to nicotine dependence
    Variant & Polymorphism other poymorphism increasing the risk of nicotine dependence
    Candidate gene potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer (Avgeris 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS