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FLASH GENE
Symbol NAT1 contributors: - updated : 24-10-2006
HGNC name N-acetyltransferase 1 (arylamine N-acetyltransferase)
HGNC id 7645
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text in pre-implantation embryos at the blastocyst stage and in early placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nat1
Homologene
FAMILY arylamine N-acetyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • drug-metabolizing enzyme active on carcinogenic arylamic p-aminobenzoil acid and the folate catabolite (pABGlu)
  • catalyzing the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Arylamine N-Acetyltransferase (Note- Not really a variation database but useful-lists alleles & nomenclature)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in bladder cancer
    Susceptibility
  • for gastric adenocarcinoma well-differentiated
  • to limb deficiency defects in the presence of maternal smoking
  • Variant & Polymorphism SNP increasing the risk of limb deficiency defects in the presence of maternal smoking
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS