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FLASH GENE
Symbol ITGA5 contributors: mct - updated : 20-05-2014
HGNC name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HGNC id 6141
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain
  • a sevenfold repeated structure (7 FG-GAP repeats) with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • The extracellular domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • recognizes the sequence R-G-D in its ligands
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • an alpha chain and a beta chain
  • alpha 5 constituent of VLA-5 receptor
  • complexing with ITGB1 in fibronectin receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by DIDO1, inducing the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS