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FLASH GENE
Symbol UPP1 contributors: - updated : 04-11-2006
HGNC name uridine phosphorylase 1
HGNC id 12576
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 stomach   highly
Endocrinepancreas   predominantly
Reproductivefemale systemovary   
 female systemplacenta  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines highly in several tumor cell lines, lowly in normal cell line
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC289801
Homologene
FAMILY PNP/UDP phosphorylase family 1
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION catalyzing the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism purine/pyrimidine
signaling
5-phospho-alpha-d- ribose 1-diphosphate biosynthesis
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
inhibited by vitamin D3, TNFA, interleukin 1 and interferon gamma
Other direct regulation of expression by p53
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in pancreatic cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • potentially useful in pancreatic tumor targeting or as tumor markers
  • ANIMAL & CELL MODELS