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FLASH GENE
Symbol PRKAR2B contributors: mct - updated : 29-03-2008
HGNC name protein kinase, cAMP-dependent, regulatory, type II, beta
HGNC id 9392
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two cyclic nucleotide binding domains
secondary structure two regulatory chains and two catalytic chains
mono polymer monomer , dimer
HOMOLOGY
interspecies homolog to murine Prkar2b
Homologene
FAMILY Camp-dependent kinase regulatory chain family
CATEGORY regulatory , signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • can act as a repressor of CREB transcriptional activity in T cells
  • may play an important role in regulating energy balance and adiposity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with CREB1 (interact with and suppress its transcriptional activity)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrant levels of nuclear PRKAR2B in systemic lupus erythematosus T cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS