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FLASH GENE
Symbol ORM1 contributors: npt/ - updated : 18/12/2008
HGNC name orosomucoid 1
HGNC id 8498
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
Reproductivemale systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   moderately
cell lineage
cell lines
fluid/secretion abundantly in plasma
at STAGE
physiological period perinatal
Text liver
PROTEIN
PHYSICAL PROPERTIES other
STRUCTURE
motifs/domains
secondary structure a single eight-stranded continuously hydrogen-bounded antiparallel beta-barrel which encloses an internal ligand binding site
conjugated GlycoP , Other
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Orm1 (52.6 pc)
homolog to murine Orm1 (50.3 pc)
Homologene
FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a crucial role in maintaining homeostasis
  • modulating the activity of the immune system during the acute-phase reaction
  • may be involved in aspects of immunosuppression
  • affecting pharmacokinetical properties of various therapeutic agents
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by glucocorticoids, interleukin-1 and interleukin-6 (increased 5- to 50-fold upon inflammation)
    Other pyrrolidone carboxylic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS