basic FUNCTION
| controlling the size of adipose depot by a profound effect of appetite and energy expenditure and regulating bone formation and bone remodeling via the sympathetic nervous system |
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involved in control of the hypothalamic-pituitary-gonadal (HPG) axis, during the development of the hypothalamus, and a neonatal critical period, preceding leptin acute regulation of food intake in adults |
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also putative angiogenic factor, playing a key role in metabolic syndrome especially in obese children |
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having proinflammatory and prothrombotic effects that could link increased adipose mass directly to atherogenesis |
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can be involved in the pathomechanism of atherosclerotic plaque formation also through its effect on cholesterol biosynthesis in monocytes |
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playing a role in blood pressure independently of obesity, and in the reproductive axis |
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acting, in part, by inhibiting the synthesis of NPY and its release from the hypothalamus |
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modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits |
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governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption |
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playing a role in the pathophysiological course of cholelithiasis |
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with LIF, CNTF, IL6, participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites |
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might significantly contribute to the production of major gel-forming mucins by direct stimulation of airway epithelial cells |
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by separately regulating EGR1 activation and synthesis, CCK and LEP interact cooperatively to define the capacity for satiety signaling by vagal afferent neurons |
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LEP, RETN, TNF may have differentiating roles in the pathogenesis of Systemic sclerosis (SSc) |
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GHRL, and LEP play an important role in the maintenance of the balance of IL17-producing and T-regulatory cells during pregnancy |
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defective central leptin signalling and impaired leptin entry into the CNS (central nervous system) represent two important aspects of leptin resistance in obesity |