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FLASH GENE
Symbol ITGB8 contributors: - updated : 26-04-2005
HGNC name integrin, beta 8
HGNC id 6163
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Reproductivefemale systembreastmammary gland  
 female systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal protein
  • a globular domain
  • a stalk region with four EGF-like repeats each with eight cysteine residues
  • VWFA-like domain
  • a single transmembrane domain (1TM)
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Itgb8
    Homologene
    FAMILY integrin beta chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION
    text type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGAV in fibronectin, VCAM1 receptors (tail)
    INTERACTION
    DNA
    RNA
    small molecule
    protein ITGAV,VCAM1 receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS