basic FUNCTION
| catalytic component of the SWI/SNF-related chromatin-remodeling complex, actin-dependent regulator of chromatin structure |
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during mitosis, phosphorylated and excluded from the condensed chromosomes |
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able to compensate for BRC1 (SMARCA4) loss as pertains to RB sensitivity |
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playing a role in the differentiation of retinal progenitors into retinal ganglion cells |
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may promote retinal ganglion cells differentiation by facilitating transcriptional activation and function of POU4F2 |
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required for villin expression, a definitive marker of intestinal metaplasia and differentiation and should play significant roles in determining the histologic features of gastric malignancy |
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central ATPase of the SWI/SNF complex, and a critical factor for the functional activity of nuclear receptor complexes |
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antagonistic roles for SMARCA2 and SMARCA4 SWI/SNF complexes in differentiation |
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with CDX2, cooperatively regulate villin expression in gastrointestinal cells |
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promote expression of distinct and overlapping MITF target genes and that at least one ATPase is required for melanoma tumorigenicity |
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SMARCA2/SMARCA4A switch is an indicator of the responsiveness of a gene to heat-shock or IFNG stimulation and may represent an "on-off switch" of gene expression |
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SMARCA2 and SMARCA4, play critical roles in regulating development of smooth muscle and SMARCA4 has specific functions within vascular and gastrointestinal smooth muscle that cannot be performed by SMARCA2 |
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expression of SMARCA2 and SMARCC2 during reprogramming was regulated by JAK/STAT3 activity |