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FLASH GENE
Symbol ST7 contributors: - updated : 08-09-2005
HGNC name suppression of tumorigenicity 7
HGNC id 11351
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
 liver    
 mouth   highly
Endocrinepancreas    
Reproductivefemale systemuteruscervix highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure twelve alpha helices with 4 turns
HOMOLOGY
interspecies homolog to murine Mray1
homolog to Drosophila Dray1
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION tumor suppressor gene(s)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in breast tumor and primary breast carcinoma, invasive epithelial ovarian cancer, myeloid disorder, acute lymphocytic leukemia
tumoral   LOH    
in acute myelogenous leukemia, acute lymphocytic leukemia, breast cancer, prostate cancer, ovarian tumor, follicular and papillary thyroid tumors
tumoral   LOH    
in sporadic renal cell carcinoma, pancreatic carcinoma, head and neck sqamous cell carcinoma, esophageal and colon carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS