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FLASH GENE
Symbol GTF2E2 contributors: mct - updated : 14-04-2016
HGNC name general transcription factor IIE, polypeptide 2, beta 34kDa
HGNC id 4651
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region of RAP 30 (the small subunit of TFIIF) with squence similarity to a sigma-factor subregion implicated in binding to RNA polymerase
  • a forkhead motif within the central region, essential for transcription, that possessed a double-stranded DNA-binding activity, and primary function of the forkhead region is dsDNA-binding in transcription with three positively charged lysine AAs which play a key role in this function
  • basic region helix-loop-helix (bHLH) motif
  • three-winged helix (WH) motifs, with one in GTF2E1 and two in GTF2E2
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine C330006j08 Rik
    homolog to C.elegans F54D5.11
    Homologene
    FAMILY TFIIE beta subunit family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ERCC3 recruitment to initiation complex
  • stimulating the RNA polymerase II C terminal domain kinase and DNA-dependent ATPase activities of ERCC3
  • plays essential roles in both transcription initiation and the transition from initiation to elongation
  • has essential roles in both transcription initiation and promoter escape
  • transcription factor essential for the assembly and stabilization of the RNA pol II pre-initiation complex (PIC) at the transcription start site
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two alpha and two beta chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
  • IFRD1 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with GTF2E2
  • IFRD1 is essential for transcription initiation by RNA polymerase II (RNA pol II) via direct interaction with the basal transcription/DNA repair factor IIH (ERCC3)
  • GTF2E2 binds to the WH domain of GTF12E1 via its bHLH domain (basic region-helix-loop-helix motif, AAs 193240)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TTDRP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS