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FLASH GENE
Symbol PTPN3 contributors: mct/npt - updated : 20-01-2010
HGNC name protein tyrosine phosphatase, non-receptor type 3
HGNC id 9655
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbrainmidbrainsubstantia nigra  
 braindiencephalon   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich, basic charged globular module
  • several (? four) PDZ (PSD95.disc large/ZO-1) domains
  • a catalytic domain in the extreme C terminal part
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text located at the cytoplasmic face of the plasma membrane (Han 2000)
    basic FUNCTION
  • tyrosine-phosphatase,non receptor,responding and participating in reorganization of membrane-cytoplasmic interactions
  • with PTPN4 are dispensable for TCR signal transduction (Bauler 2008)
  • inhibits T cell activation by dephosphorylating membrane-associated targets involved in TCR signaling (Han 2000)
  • seems to play an important role in gastric cancer differentiation and the progression of malignancy (Wu 2006)
  • having a controlling role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion (Pilecka 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting protein of SCN5A (Jespersen 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS