basic FUNCTION
| antineutrophil antibacterial peptide, involved in oxygen independent phagocytosis of Gram+, Gram- bacteria, many fungi, some viruses |
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function of the conserved salt bridge in DEFA4 is not linked to bactericidal activity or proteolytic stability of the mature peptide |
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antimicrobial and chemotactic activity of DEFA4 is somewhat comparable to that of other human neutrophil defensins |
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had no intrinsic transcriptional activity, but exhibited adaptor function, because it acted synergistically with serum response factor (SRF) and GATA6 to activate the smooth muscle (SM)-alpha-actin promoter |
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translocate cooperatively across phospholipid bilayers |
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its translocation has implications for its antimicrobial activity as internalized peptide would be available to attack intracellular targets |
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has likely selective bactericidal activities against intestinal microbiota and the activities are dependent on the disulfide bonds |