Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ART3 contributors: mct/npt - updated : 25-08-2008
HGNC name ADP-ribosyltransferase 3
HGNC id 725
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • two disulfide bonds
  • a hydrophobic peptide signal at its N terminus
  • three consensus motifs specific to enzymes catalyzing ADP-ribose transfer
  • a hydrophobic C-terminal sequence characteristic of a GPI-anchored protein with a novel motif repeated 3 times and a potential
  • glycosylation site
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans R08A2.2
    Homologene
    FAMILY
  • mono (ADP-ribosyl) transferase family
  • Arg-specific ADP-ribosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text GPI anchored membrane protein
    basic FUNCTION
  • transfering an ADP-ribose moiety from NAD+ to a specific amino acid in the target protein
  • exerts a specific function only required at a particular stage of spermatogenesis
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NAD
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-obstructive azoospermia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS