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FLASH GENE
Symbol HPGD contributors: mct/npt - updated : 15-07-2008
HGNC name hydroxyprostaglandin dehydrogenase 15-(NAD)
HGNC id 5154
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly
 female systemuterus  highly
Respiratorylung   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Hpgd
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catabolic enzyme controling the biological activities of prostaglandins by converting them into inactive keto-metabolites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CRHR1 and CRHR2 (mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    ANIMAL & CELL MODELS